Genectic for cancer

Familial 1% Breast ca gens

P53
PTEN
SKT11
CDH1
ATM
CHEK2
PALLPB2

familial breast ca 99%

• BRCA1 & BRCA2

ER,PR + gene

Pi3CK

Thyroid Cancer

• FAP
• Gardeners
• MEN1
• MEN2a
• cowden
• crynway

Follicular ca

• miRNA => 197,349
• PTEN
• BAX

Pancreatic cancer genes

• STK11 Peutz-Jeghers syndrome: ↑ Risk of pancreatic cancer by 100 folds.
• Familial atypical mole & multiple melanoma syndrome.
• Cystic fibrosis.
• BRCA-2 gene mutation.
• Lynch-2 syndrome.
• Familial adenomatous polyposis: ↑ Risk of periampullary cancer, pancreatic ductal adenocarcinoma

Colon polyp to cancer

• juvinile polposis syndrome ⇐ SMAD 4 gene
• Petuz jeghers syndrome ⇐ STK-11/ LKB-1 on Ch19
• cowden syndrome ⇐ PTEN ch10
• FAP syndrome - APC gene mutation
• HNPCC - MLH1, MSH2 gene