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3.Lymphoma

  • Enlargment of Lymphnode
Reactive Lympadenopathy Lymph node Enlargment
Painfull Painless
Infection Chronic immune response ,Neoplasia

Classification of Neoplastic Lymphoma

graph TD



    subgraph Non-Hodgkin

    Xya ==>Xya1[Activated B-cell Producing Immunoglobulin]
    Xya1 ==> Xya2["`***t(14;18)***, IgH replaced with BCL~2~`"];
    Xya2 ==> xya3["`Blc~2~ anti-apoptotic`"] 
    xya3 ==> xya4[Uncontrolled growth];

    Xyb ==>|un-activated B-cell| Xyb1["`t(11;14) Ig HEavy chain replaced with Cyclin D1`"];
    Xyb1 ==> Xyb2[from G1 to S phase];
    Xyb2 ==> Xyb3[Unci=ontrolled growth]


    Xyc ==>Xyc1[Old Activated Class Switched B-cells];
    Xyc1 ==> Xyc1a[from Chronic Disease like
    Hashimoto Thyroididtis
    Sjogren Syndrome,
    MALToma or H.pylori];




    X11c ==> X11c1["`t(8:14) `"]
    X11c1 ==>|c-myc translocated to  IgH gene| X11c2[Burkitt Lymphoma];
    X11c2 ==>|appreance| X11c5["`Stary Sky appearance due to High Mitotic`"];
    X11c2 ==>|types| Xc11[African type on the Cheeks] & XC12[Sporadic Type on the Abdomen];

    X11d ==>|Large Undifferentiated Diffuse Type| X11d1["`***M/C Lymphoma*** 
    clinically aggressive`"];

    end

    subgraph Types
    X[Neoplasm  Lymph node ] ==>|Filled with Neoplastic Cells| X1[Non-Hodgkin lymphoma];
    X1 ==>|Classification| X1a[1.Cell type
    2.Cell size
    3.Markers 
    4.Translocation
    5.Pattern of Growth]
    X1a ==> X11a[Cell size]
    X11a ==> X11b[Small cell] & X11c[Intermediate] & X11d[Large cell]
    X11b ==>|region| Xya[Follicular] & Xyb[Mantle] & Xyc[Marginal];
    end 

    subgraph Hodgkin Lymphoma 
    X ====>|Filled with Recruited Cells| X2[Hodgkin lymphoma];
    X2 ==> XVV[Reed Sternberd Cells CD5+ ,CD30+
    recruiting Cells to Lymph node ]
    XVV ==>|Based on Recruited Cells| 9[types of Hodgkin]
    9 ==> X2a[Nodular Sclerosing]
    X2a ==>|Appreance of Reed Sternberg cell| X2a1["` Lacunar Apperance `"];
    9 ==> X2b[Mixed Types ];
    9 ==> X2c[Lymphoid Rich] & X2d[Lymphoid depleted];
    X2c ==> X2c1["`***Popcorn Cells*** , good Prognosis`" ];
    X2d ==> X2d1[older& HIV patients ,worst prognosis];
    end

Age of Onset

  1. Follicular - Late adult
  2. MAntle - LAte adulthood
  3. MArginal - late adulthood
  4. burkitt - kids
  5. Large cell - *M/C *** late adulthood ,aggressive.

Chromosome

  1. Chromosome 14 - HEavy chain
  2. Ch 8 - c-myc
  3. Ch 11- Cyclin D1 (11 - cyclID)
  4. Ch 18 - Bcl2