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4.Multiple Myeloma

  • Malignant proliferation of Plasma cells in Bone marrow
  • Producing Antibodies
Follicular Lymphoma Marginal Lymphoma Multiple Myeloma
Location of Neoplastic cells Lymph node Follicular region Mucosal surfaces,Spleen,Lymphnode Bone marrow
Cell type Mutated B-cell Memory B-cells of CHronic Inflamatory Diseases New plasma cells producing Antibodies 
graph TD
    X[Plasma Cells] ==> X1[Producing Antibodies];
    X1 ==> X1a[Symptoms based on Antibdy type and Hypersecretion];
    X1a ===>|RANK ligand ANtibodies| X1aa[Activation Osteoclasts]
    X1aa ==> X1ab[Lytic Lesion on Bone and Hypercalcemia];
    X1a ==>X2[Elevated Serum Protein]
    X2 ==> X2a["`M-spike by ***IgG,IgA*** on SPEP (no IgM or IgD) `"];
    X2 ==> X2a[Ig-Protein Excreted in Urine];
    X2a ==> X2ab["`***Bence-Jones Proteinuria***];
    X2 ==>|loss of RBC charge| X2c[Roleux Formation of Rbc];
    X1a ==>|elevated Ig light chain Produced| X3[Primary Amyloid deposition in Organs];
    X3 ==>|deposition on Kidneys| X3a[Myeloma Kidney];
    X1a ==>|Only Monoclonal ANtibody| X4a["`Lack of Polyclonal ANtibody - ***M/C cause ofDeath*** Infection`"]

2.MGUS (Monoclonal Gammapathy Undermined Source]

  • ELderly
  • Elevated Serum Protein ➡️ SPEP ➡️ M-spike
  • No Lytic Lesion,No Hyper-Calcemia,No Bence-Jonce Protein,No Amyloid Deposit ➡️ 🤔 MGUS

MGUS

3.Walderstrom Macroglobulemia

  • Macroglobulin = IgM(Pentamere Large Size)
  • B-cell Lymphoma with only IgM
  • Elevated Serum Protein ➡️ SPEP ➡️ M-spike ( IgM )
  • ⬆️ Viscosity of blood ➡️ Retinal detachment, neurological Defect,⬇️ platelet Aggregation.