1.Acute Leukemia¶

Neoplasia of Blast cells

Normal Hematopoiesis¶

graph TD
    X[Hematopoietic stem Cell]


    subgraph Myeloblast 
    Xxa[Common Myeloid Progenitor]
    Xxa ==> X1[Megakaryocyte And Erythroyte Progenitor] & X2[Granulocyte and Monocyte Progenitor cells];
    X2 ==> X2a[Granuloblast ] & X2b[Monoblast]
    X2b ==> X2b1[Macrophages]
    X2a ==> X2a1[Neutophils] & X2a2[Basophils] & X23[Esonophils];
    X1 ==> X1a[Megakaryoblast] & X1b[Erythroblast];
    X1a ==> X1aa[Megakaryocytes] 
    X1b ==> X1ba[RBC]
    end

    subgraph Lymphoblastic
    Xxb[Common Lymphoidal Progenitor];
    Xxb ==> Y[Lymphoblast]
    Y ==> Y1[B lymphobalst] & Y2[T lymphoblast] & Y3[Nk cell progenitor]
    Y1 ==>Y1a[B cell] 
    Y2 ==> Y21["`CD4~+~/T~h~ cells `"] & Y22["`Cd~+~/Cytotoxic T cell`"]; 
    end

    X ==> Xxa
    X==> Xxb
    Y3 ==> y3a[NK cell];

Acute Leukemia¶

graph TD
    X[ Neoplastic Accumulation of Blast];

    subgraph AML
    X ==>|+Auer Rods| X1["`AML(Acute Myeloblastic Leukemia)`"] 
    X1 ==>|classified into| 1[Cyogenetic Abnormalities] & 2[Lineage] & 3[Mylodyspalstic Syndrome ] & 4[from Chemotherapy]
    1 ==> 1a["`t(15;17)`"]
    1a ==>|gene for receptor for Retinoic acid| 1a1[Acute Pro-myelocytic Leukemia]
    2 ==>|Prolifertion of Megakaryocytes| 2b[Acute Megaloblastic Leukemia]
    2 ==>|Neoplastic Proliferation of Monoblast| 2a[Acute Monocytic Leukemia]

    3 ==>3a[from Prior Chemotherapy into AML]
    end

    subgraph ALL
    X ==>|+ tDt| X2[ALL]
    X2 ==>X22[based on CD markers]
    X22 ==>|CD10,19,20,21| X22a[B-ALL]
    X22 ==>|CD2,3,4,5,6,7,8| X22b[T-ALL]
    end