Anemia

• *** Reduction in the total Mass(volume) of circulating RBC* reduction in Oxygen carrying capacity

How u measure RBC mass of total blood ?

• We use Surrogates like HB,MCV,Hct,RBC count

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1. HCT - percentage of Rbc in the blood [Ex:45% of RBC , 55% plasma, >1% WBC]
2. Hb - percentage of protein (Hemoglobin) per volume [Ex:12.5g/dl]
3. MCV(mean cell/Corpuscular volume) - Average size of RBC [Example;80/fl]

• Problems with HB,HCT,Rbc count
  1. Haemorrhage loss of RBC and fluid but normal HB,HCT in the sample.
  2. IV infusion increase in plasma HCT,HB,RBC count due to volume change

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Anemia based on MCV(Mean size of RBC)

graph TD
    X[MCV] ==> X1[Microcytic Anemia] & X2[Normocytic Anemia] & X3[Macrocytic Anemia]

    subgraph MCV
    Ya[Microcytic <80]
    Y1[Normocytic 80-100]
    Y2[Macrocytic 100<]
    end