Regeneration/Repair after Inflammation¶

Factors Promoting Wound Healing¶

Secreting Cell	Growth FActors	Time of Secretion	Function
Epithelium	TGF-alpha	Epithelial Damage	SKin.Mucosal growth
Macrophage	IL-10,TGF-beta	at the of end inflamamtion	Fibroblast for Collagen 3 secretion
Platelets	PDGF	after clot	Enothelium,Smooth muscle and Fibroblast growth
Blood Vessels	VEGF	Blood vesssel damage	Angiogenesis of Blood vessels
Fibroblast	FGF		Angoigenesi, Growth of Skeletal Mucle

graph TD
    X(Healing) ====> X1[Regenaration- regeneration to Old cells] & X2[Repair- Scar formation];
    X1 ==>|new cells from stem cell| X1a[Skin,Liver,bone,Rbc,Lungs Parenchyma]
    X2 ==>|"`***absence of Stem cell or loss of Stem cells***`"| X2a[Myocardium,deep cut in Skin,Neurons,Skeleton muscles];

Types of Wound Healing¶

Primary healing = Skin close with Suture.minimum scar formation
Secondary Healing = Skin not close enough ,scar tissue fills the gap

Normal Healing Process¶

graph TD
    X[Steps of Healing] ===>X1[Granulation Tissue formation]
    X1a[1. Fibroblast Collagen-3 Deposition
    2. Capillaries formation for Nutrients 
    3. Myofibroblast to Contract the skin together]-.->X1;
    X1 ==> X2[Removal of Granulation Tissue];
    X2 ==>X3[Scar]
    X2a("`***Collagenase with Zn removal
    Type 3 Collagen and replace type 1 Collagen***`") -.-> X2;

Causes of Delayed Healing¶

Infection
Problems in Collagen
1. Vitamin C ,Zinc ,Copper deficiency
Presence of Foreign Body,ischemia,Diabetes

Disease of Abnormal Healing¶

Keloid	Hypertropic Scar
Over deposition of Type 3 Collagen	Over Deposition of Type 1 Collagen
M/C in African American
Ear lobes ,face,upper Extremities