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2.Immune cells to site of Injury

graph TD
    X[Injury] ==> x1a[Margination];
    x1a ==> x1b[Rolling];
    x1b ==>x1c[Adhesion]
    x1c ==> x1d[Migration];
    x1d ==> x1e[Acton]; 
    x1e ==> x1f[Apoptosis of Neutrophils];
    x1f ==> x1g[Macrophage response by phagocytosis];
    x1g ==> x1ga[Healing and Resolution] & x1gb[Inflammation];
    x1gb ==>|either|  xga[IL-8 Netrophil recruitment] & xgb[Antigen Presenting for Chronic Inflammation];

Steps of Recruitment

  1. Margination

    • Leukocytes reach the marigin of the vessel due to Arteriole Dilation and Increased Capilary Permeability

  2. Rolling 

    graph TD
    X[types of Endothelial Selectins] ==> x1a[P- selectins from Weibel-Palade bodies activated by histamine] &         x1b[E-Selectins induced by Il-1,TNF];
    • rolling of Leukocytes by One type of Selectins of Endothelium
    • Binding to Sayl Lewis X on the Leukocytes

  3. Adhesion

    • Strong Adhesion by CAMs of endothelium by TNF and IL-1 with Integrins of Neutrophil by LTB4,C5a activation

Leukocyte Adhesion deficiency

  • Autosomal Recessive Disease of CD18(Integrin) failure to expressed , leads to failure of Neutrophil adhesion to Endothelium
  • Lack of Pus formation
  • Elevated Neutrophil (Lack of Integrin for attachment to rest on lUngs)
  • Failure of Umbilical cord Separation (no Acute inflammation for umbilical Cord Separation)

  1. Migration to the region

    • By chemotaxis IL-8,LTB4,C5a

  2. Phagocytosis

    • enchanters IgG,C3b

Chediak-Higashi Synndrome

  • Autosomal Recessive Disease in failure of abnormal Microtubule formation,leads to defect in intracellular transport
  • Albinism(cannot send Melanin to Keratinocytes)
  • Neutropenia(Failure to move sister Chromatids)
  • GAint granules in Neutrophil in Golgi(failure to distribute )
  • Defective Primary Hemostsis (Platelet granules distribution defect)
  • Peripherial Neuropathy(Failure to Transport substance to end of Axon)