Cell Adaptation¶
graph TD
X[Normal cell] ==>|stress| X1[Cell adaptation];
X1 ==> X1a[Hypertrophy] & X1b[Hyperplasia] & X1c[Metaplasia] & X1d[Dyspalsia] & X1e[Atrophy];
1. Hyperplasia¶
- Cells that can multiple
| Physiologic | Patholagic |
|---|---|
| Hormonal Physiologic Hyperplasis - Breast during Puberty,Uterus Smooth muscle | Endometrial hyperplasia cancer from estranged hypersection |
| Compensatory Physiologic Hyperplasis - Liver cell hyperplasia after liver Transplant | Benign Prostatic Hyperplsia |
Hypertrophy¶
- Mainly cells that cannot Replicate, and few exception
| Physiologic | Pathologic |
|---|---|
| Physiologic Hypertrophy of SM of Uterus during pregnancy | Hypertrophy of Left ventricle due to Aortic stenosis, HTN |
Atrophy¶
- Opposite to both Hypertrophy,due to loss of Function(limb atrophy after paralysis),insufficient supply of Nutrients,Physiology Atrophy(Endometrium after menopause_
- Cell size(Lysosomal degradation and Autophagy)
Metaplsia¶
- Change for one cell type to a better cell type to withstand the new stress
-
Sxamples > Stratified Squamous Epithelium to Non-Cliated Columnar Epithelium due to Acid reflex > Ciliated Columnar epithelium to Statified Squmous epithelium due to continuous cigarette smoking > Myositis Ostification replacement of SKeletal Muscle with Bone tissue due extensive damage to muscles
-
Uncontrolled Metaplsis leads to carcinoma
Dysplasia¶
- Disorder growth of cells
- Precursor to Cancer
- Can be reversed by removal of Stress