Rabies

bullet shaped virus

graph TD
    A[rabid animal bite];
    B[virus replication at local muscle ];
    C[binds to nicotinic receptor of muscle  ];
    D[then binds to neuron G protein or CD56 and then endocytosis into neuron ,Retro-ggrade transport up to spinalcord ];
    E[via Dorsal root ganglion];
    F[Brain];
    G[Spread to other tissues via peripheral neurons];
    H[Presentation of symptoms like hydrophobiaa, salivary shedding of virus];
    I[Cns symptoms hallucination ,coma];
    J[Death];

    A -->B;
    B --> C;
    C --> D;
    D --> E;
    E --> F;
    F --> G;
    G --> H;
    H --> I;
    I --> J;

Diagnosis

1. Clinical Presentation
2. Negri bodies found on brain autopsy