Anti-microbials

Anti-bacterial agents

graph LR
    X{Anti-microbials} ==> Z{Beta-lactam};
    X ==> Zy[Prevention of Protein Synthesis];
    X ==> Zz[Folate Metabolism Inhititors];
    Zz ==> Zz1[Sulfanamides];
    Zz ==>|inhibit DHF reductase| Zz2[Trimethoprim
    Pyrimethaprime]
    Z ==>x1{Penicillins}
    Z ==>x2{Cephalosporins};
    Z ==>|inhibit D-ala,D-ala joining on Peptidoglycan wall| x3{Vancomycin};
    x3 ==>x3a[used against MRSA];
    Zy ==>| Binds to 30S Subunit = Stop Protein Synthesis| Zy1{Amino-glycosides};
    Zy1 ==>|gram Negative rods| Zy1a[Getamycin, Tobramycin,Amikacin];
    Zy ==>|binds to A site of Ribosome| Zy2[Tetracyclines];
    Zy2 ==> Zy2a[Doxcycline
    Minocycline];
    Zy ==>|Prevents Peptidyl-Transferase bond Formation| Zy3[Chloramphenicol];
    Zy ==>|Binds to 50S subunit| Zy4[Macrolides];
    Zy4 ==>|Also used on Penicillin Allergic Patients| Zy4a[Azithromycin
    Erythromycin
    Clarithromycin used for H.pylori regimen];
    Zy ==>|similar to Macrolides| Zy5[Clindamycin =Treat infection in Bone];
    x1 ==>|Original Penicillin| x1a[1.Penicillin G and V];
    x1a ==>|Only few organisms respect it| x1a1[Syphilis, Streptococcus ];
    x1 ==>|later slightly modified| x1b[2.Methicillin group];
    x1b ==> x1b1[Stap.Aures];
    x1 ==>|modified for g- coverage| x1c[3.Amoxicillin, Ampicillin ];
    x1c ==>|covers gram -| x1c1[E.coli,H.influenza,Listeria,H.pyroli....];
    x1 ==>|Pseudomonas Coverage| x1d[4.Pipercillin,Ticarcillin];
    x1 ==>|added with Penicillins to inactivate Beta lactamase enzyme| x1e[Clavulanic acid,Sulbactum,Tazobactum];