Toxocolgy

Activated Charcoal

• 1g/kg {OR} 50-100g / 10:1 (AC: xenobiotic ratio) and within 240 minutes of exposure.
• at 1:8 ratio mixed in water
• Single dose Acivated charcoal
• Multi-dose activated charcoal
  • for prolonged relase toxin
  • Enteric coated toxins
  • impaired GI motility
  • reabsorption can be prevented by active hepatic toxin release
  • Best at varying degree in
    • Amitriptyline
    • Cyclosporine
    • Carbamazepine
    • Dapsone
    • Digitoxin
    • Nadolol
    • Nortriptyline
    • Phenobarbital
    • Phenylbutazone
    • Propoxyphene
    • Quinine
    • Salicylate
    • Theophylline

Function

• Absorption of drugs
• Prevent enterohepatic and enteroenteric recirculation

Not absorbed by Activated Charcoal

• Alcohols
• Acids
• Alkalis
• Iron
• Lead
• Lithium
• Magnesium
• Potassium
• Sodium salts

Rate of Absorption

• efficacy of absorption is Inversly proportional to time and absortion rate of toxin

AC de-osption

• PH change
• Fatty acid stuck to AC and prevent toxin absorption